GIC LAB @ DGIST
Our Research
Cancerous cells accumulate numerous harmful genetic aberrations, yet they can override normal cellular checkpoints and continuously proliferate. They seem to do so, in part, by taking advantage of cellular recovery pathways. We aim to identify new pathways that cancers rely on for survival, with the ultimate goal of providing new anti-cancer therapeutic logistics.
Research Summary
Maintenance of genomic integrity is essential for all life forms. Loss of genomic integrity can lead to various abnormalities, including cell death, aging, and cancers. Understanding the molecular processes that preserve genomic integrity is important in biological and clinical sciences.
RESEARCH SUMMARY
Cancers develop therapy resistance via multiple mechanisms. Some of these refractory cancers may rely on heightened activities of genome-stabilizing pathways. We use synthetic lethality approaches to identify new genetic dependencies of cancers.
RESEARCH SUMMARY
We employ a range of experimental tools to decipher functional and structural features of genome-stabilizing factors. These information may provide new avenues for anti-cancer strategies.
Research Tools
We use a variety of modern technologies to tackle our research hyothesis
Our Collaborators
George-Lucian Moldovan Lab
@ PennState Univ., USA
With the Moldovan Lab, we design genome-wide CRISPR knockout screens to identify new synthetic lethality factors in various cancer genetic backgrounds
Tony Huang Lab
@ NYU, USA
With the Huang Lab, we study the role of DNA repair and Fanconi Anemia proteins in replication fork stress response
Chosun Univ. MRC Labs
@ Gwangju, Korea
With the several MRC labs, we explore roles of DNA homologous recombination repair factors and genomic instability. We also study role of RNA metabolizing factors and stress granules
Center of Genomic Integrity, IBS/UNIST
Korea
With the IBS/CGI and UNIST labs, we study the role of DNA replication factors and chemotherapeutic drugs in genomic stability and cellular survival
DGIST Labs
@ Daegu, Korea
With Jinhae Kim Lab, we use NMR to study role of disordered structures in protein-protein interactions
With Youngtae Jeong Lab, we study role of DNA repair proteins cancer drug resistance in cancer organoid models
With Minsik Kim Lab, we interrogate proteomic changes under genotoxic stresses
With Jong-Chan Lee Lab, we interrogate phase separations of DNA repair and replication fork-associated proteins
Gaelle Legube Lab
@ Univ. of Toulouse, France
With the Legube lab, we use genome-wide Chromatin Immunoprecipitation-sequencing to identify protein enrichment regions in chromatin
Youngju Lee Lab
@ Pusan Univ., Korea
With the Lee lab, we utilize PROTAC and RIBOTAC technologies to selectively target and inactivate DNA damage response or cancer-promoting factors in cancer cells
Jihye Paik Lab
@ Cornell Univ. Weil Medical School
With the Paik lab, we interrogate mechanisms that support telomere integrity in glioma and other types of cancers.